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One Health interventions to prevent or reduce the development and transmission of antimicrobial resistance

Funding Call Details

One HeAlth InteRventIon and TransmiSSion in AMR

Antimicrobial resistance (AMR) does not recognise geographic borders or species barriers. Progress on AMR is necessary to achieve the United Nations (UN) Sustainable Development Goals (SDGs), with AMR being deeply rooted into attainment of SDGs promoting no poverty, good health and wellbeing, zero hunger, reduced inequality and decent work and international growth. With the current focus of the JPIAMR Strategic Research and Innovation Agenda, this call will specifically focus on tackling the rising threat of antibiotic resistance. Addressing the rising threat of antibiotic resistance requires a One Health approach since resistant bacteria, genetic elements and antibiotics are found in humans, animals and the environment. Declining clinical effectiveness of existing antibiotics together with the low and insufficient number of promising new antibiotics in the pipeline stresses the urgency to understand the mechanisms of emergence and transmission of antibiotic resistance. The European One Health Action Plan against AMR1 encourages the EU and its Member States to deliver innovative, effective and sustainable responses to AMR, especially to reduce the emergence and spread of AMR inside and outside the EU. This call, funded under the ERA-NET JPIAMR-ACTION, is the 13th JPIAMR transnational call for research projects. The call advocates for a One Health approach to 1) understand the impact of interventions on the development and transmission of antibiotic resistance and to 2) design, implement, evaluate, and compare interventions that will have a true impact on preventing or reducing the development and transmission of antibiotic resistance in and between the different One Health settings (human, animal, environment).

Research is needed to understand antibiotic resistance development and transmission and to develop interventions in various geographic and socio-economic settings, to design One Health implementation strategies, and to test their cost-effectiveness, efficiency and uptake2. Factors including the heterogeneity of culture and behaviour, healthcare systems, prescribing practices and consumption of antibiotics, water utility and sanitary routines, agricultural practices, pharmaceutical manufacturing processes, sewage/effluent management and treatment, and resistance to antibiotics across the globe, including in low and middle-income countries (LMICs), warrant different implementation approaches.

In addition to inviting researchers from participating countries, this call intends to support and increase the participation and leadership of researchers from LMICs3 in transnational research projects. Antibiotic resistance thrives in settings with limited access to water and sanitation, medicines, veterinary and human health care, and in geographic locations where antibiotics are produced and used and pose increased and unknown risks for humans, animals and the environment. Research and innovation in these types of settings, often prevailing in resource-limited contexts, are essential to prevent or reduce the local development and transmission of antibiotic resistance and is of great importance for our collective global future.

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